Tuesday Apr 04, 2023
Lead: Genome-wide association study identifies loci underlying multiple substance use disorders
Lead Story:
Nature Mental Health
Recent large-scale genome-wide association studies (GWASs) show that the genetic architecture of substance use disorders (SUDs) is characterized by a high degree of commonality, i.e., a general addiction genetic factor likely conveys vulnerability to multiple SUDs. Genetic liability to substance use disorders can be parsed into loci that confer general or substance-specific addiction risk. This is a multivariate genome-wide association meta-analysis that disaggregates general and substance-specific loci from published summary statistics of SUDs. Findings provide insight into genetic risk loci for substance use disorders that could be leveraged as treatment targets.
Version: 20241125